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780 and 1940 nM for ROCK1
Nicole Buschmann
Ki16425 also significantly reduces the NGF-induced stimulation of p42/p44 MAPK and inhibited NGF-stimulated neurite outgrowth in PC-12 cells
Treisman R
222638-67-7
OTS-964 hydrochloride - CAS# 1338545-07-5 054 780 and 1940 nM forOTS 964 hydrochloride, CAS No. 1338545 07 5, hydrochloride is a potent and selective TOPK inhibitor with potential anticancer activity. OTS964 inhibits TOPK kinase activity with high affinity and selectivity. Similar to the knockdown effect of TOPK small interfering RNAs (siRNAs), this inhibitor causes a cytokinesis defect and the subsequent apoptosis of cancer cells in vitro as well as in xenograft models of human lung cancer. Although administration
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