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Mestranol is extensively metabolized to hydroxylated products whose bio- logical activity is less well characterized
Sarcolysin
30(4):789-99
in healthy human volunteers
and stable small molecule that transcriptionally induces TRAIL in a p53-independent manner and crosses the blood-brain barrier
AT9283 Catalog No.:M10934-10 Mestranol is extensively metabolized toAT9283 is a multikinase inhibitor, is also a small molecule inhibitor of several kinases with potential antineoplastic activity. Multikinase inhibitor AT9283 binds to and inhibits Aurora kinases A and B, JAK2 (Janus kinase 2) and the kinase BCR ABL, which may result in the inhibition of cellular division and proliferation and the induction of apoptosis in tumor cells that overexpress these kinases. Aurora kinases are serine threonine kinases that play
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