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CAS Number: 356559-20-1
de Haven Brandon AK
Local delivery of novel MRTF/SRFinhibitors prevents scar tissue formation in a preclinical model of fibrosis
Chemical Name: (R)-2-((6-((3'-(aminomethyl)-5-methyl-[1
InChi: InChI=1S/C15H10O5/c1-6-2-8-12(10(17)3-6)15(20)13-9(14(8)19)4-7(16)5-11(13)18/h2-5
bpV(phen) trihydrate 310 CAS Number: 356559-20-1bpV(phen) trihydrate, a insulin mimetic agent, is a potent protein tyrosine phosphatase (PTP) and PTEN inhibitor with IC50s of 38 nM, 343 nM and 920 nM for PTEN, PTP and PTP 1B, respectively. bpV(phen) trihydrate inhibits proliferation of the protozoan parasite Leishmania in vitro. bpV(phen) trihydrate strongly induces the secretion of a large number of chemokines and pro inflammatory cytokines, and it activates a Th1 type pathway (IL 12, IFN).
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