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It is an analog of clinical IDH2 inhibitor AG-221 by Thomson Reuters Integrity analysis
In vivo CUDC-101 promotes tumor regression in various cancer xenograft models such as non-small cell lung cancer (NSCLC)
proliferation of the tumors in HCT116 xenografts
and was discovered by an imaging-based screen
AMD 3465 treatment stimulates the phosphorylation of Erk1/2 in U87 and Daoy cells
ISX9 - Neurogenic Modulator. CAS# 832115-62-5 0249 It is an analog ofISX9, CAS No. 832115 62 5, is a neurogenic modulator. It mediates neuroD reporter gene induction via activation of Ca2+ influx, and increases expression of neurogenic differentiation 1 (NeuroD1) transcription factor. It induces neuronal differentiation in human cortical neuronal cells (HCN), adult mouse whole brain (MWB) and subventricular zone (SVZ) progenitors. ISX9 is also shown to induce cardiomyogenic differentiation of Notch activated epicardium
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