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PubMed PMID: 22948716
3-d]pyrimidin-4-yl) piperidin-4-yl)-1H-benzo[d]imidazole-5-carboxylate
CAS Number: 2451573-87-6
InChiKey: IBCXZJCWDGCXQT-UHFFFAOYSA-N
inhibits TGF-β and activin signaling by suppressing Smad3 phosphorylation without affecting the MAPK/p38
PKI-587 stin PubMed PMID: 22948716PKI 587is an agent targeting the phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in the PI3K mTOR signaling pathway, with potential antineoplastic activity. Upon intravenous administration, PI3K mTOR kinase inhibitor PKI 587 inhibits both PI3K and mTOR kinases, which may result in apoptosis and growth inhibition of cancer cells overexpressing PI3K mTOR. Activation of the PI3K mTOR pathway promotes cell growth, survival,
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