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5 μM against all other PDE isoforms
The effects of intravenous ADP infusions of 2-8mg/kg/hour were examined in anesthetized Wistar rats that were untreated or chronically pretreated with clopidogrel
InChi: InChI=1S/C38H47NO11/c1-7-28(26-21-33(46-4)36(48-6)34(22-26)47-5)37(42)39-18-9-8-13-29(39)38(43)50-30(25-11-10-12-27(20-25)49-23-35(40)41)16-14-24-15-17-31(44-2)32(19-24)45-3/h10-12
InChi: InChI=1S/C27H33F3N2O2/c1-25-14-12-18-16(8-11-22-26(18
berghei ANKA) appearesd on Day 17 and all mice of this group died by Day 21
GGTI-2418 14533 5 μM against all otherGGTI 2418 is a highly potent, competitive, and selective geranylgeranyltransferase I (GGTase I) inhibitor. GGTI 2418 inhibits GGTase I and FTase activities with IC50s of 9. 5 nM and 53 M, respectively. GGTI 2418 also increases p27(Kip1) and induces significant regression of breast tumors. Product information CAS Number: 501010 06 6 Molecular Weight: 441. 52 Formula: C23H31N5O4 Chemical Name: (2S) 2 {[(2S) 2 benzyl 4 [(5 methyl 1H imidazol 4 yl)methyl]
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