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Gaboxadol hydrochloride (Lu 02-030 hydrochloride
Solubility: DMSO: 58 mg/mL(199
24 hours) decreases the viability of HeLa cervical cancer cells (IC50=15 µM)
26)14-9-11-17-16(18(22)15-19(17)23)10-7-5-6-8-12-20(24)25/h9
3S)-2-(3-chlorophenyl)-3
5, 15-DPP Size:Contact [email protected] for quotation Gaboxadol hydrochloride (Lu 02-030 hydrochloride5,15 diphenylporphyrin (5,15 DPP) is a selective STAT3 SH2 antagonist . Stat3 is constitutively activated in many human cancers. Stat3 functions as a critical mediator of oncogenic signaling through transcriptional activation of genes encoding apoptosis inhibitors, cell cycle regulators and inducers of angiogenesis . Aberrant STAT3 activity has been associated with transforming mechanisms induced by oncogenic tyrosine kinases . In vitro: 5,15 DPP
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