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The molecular targets of CE and DBZ are the N-terminal fragment of presenilin 1 within the γ-secretase complex
Madrasin (10-30 μM
AS601245 (0
Combined therapy with AG-490 and IL-12 induces greater antitumor effects than either agent alone in a murine myeloma tumor model
An intermediate growth inhibitory effect is observed with (±)-Gossypol but this effect is only observed at the higher dose of Gossypol (10 μM
SD-36 Catalog No.:M13867-2 The molecular targets of CESD 36 is a potent and efficacious PROTAC STAT3 degrader (Kd=~50 nM), and demonstrates high selectivity over other STAT members. SD 36 also effectively degrades mutated STAT3 proteins in cells and suppresses the transcriptional activity of STAT3 (IC50=10 nM). SD 36 exerts robust anti tumor activity, and achieves complete and long lasting tumor regression in mouse tumor models. SD 36 is composed of the STAT3 inhibitor SI 109, a linker, and an analog of
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