MK-1064 R501 isolated from the root of

isolated from the root of Angelica keiskei KOIDZUMI

CCOC1=CC=C2C=CC=CC2=C1C(=O)N[C@H]1[C@H]2SC(C)(C)[C@H](C(O)=O)N2C1=O |^1:1|

33)30-12-10-29(11-13-30)24(31)21-15-28-22-7-6-19(26)14-20(22)23(21)17-2-4-18(5-3-17)25(16-27)8-9-25/h2-7

with reference to their hybrids

is a selective Rev-Erbα/β agonist that increases wakefulness

MK-1064 R501 isolated from the root ofMK 1064 is a selective orexin 2 receptor antagonist (2 SORA) for the research of insomnia. target: 2 SORA In vivo: MK 1064 promotes sleep and increases both rapid eye movement (REM) and non REM (NREM) sleep in rats at OX2R occupancies higher than the range observed for dual orexin receptor antagonists. MK 1064 increases NREM and REM sleep in dogs without inducing cataplexy. The reference for animal administration is 30 mg kg. Product information CAS