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Solubility: DMSO: ≥ 56 mg/mL
2013 Nov 16
JNK/SAPK1c with IC50s of 80
prevents GGTI298/TRAIL-induced IκBα and p-Akt reduction
CHIR-124 potentiates the growth inhibitory effects of Irinotecan by abrogating the G2-M checkpoint and increasing tumor apoptosis in an orthotopic breast cancer xenograft model
Motesanib (AMG-706) idipine Solubility: DMSO: ≥ 56 mg/mLMotesanib, also known as AMG 706, is the orally bioavailable multiple receptor tyrosine kinase inhibitor with potential antineoplastic activity. Motesanib selectively targets and inhibits vascular endothelial growth factor (VEGFR), platelet derived growth factor (PDGFR), kit, and Ret receptors, thereby inhibiting angiogenesis and cellular proliferation. Product information CAS Number: 453562 69 1 Molecular Weight: 373. 45 Formula: C22H23N5O Synonym: