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AV-412 free base Size:Solid 10 mg a Rho-kinase inhibitor

SKU: 83551414857

4.1
USD95.00 USD140.00

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Description

a Rho-kinase inhibitor

20)11-5-3-4-9-10(15(26)12-6-1-2-7-24-12)8-13(17(21

Sacubitril (AHU-377) is converted by enzymatic cleavage of the ethyl ester into the active neprilysin inhibiting metabolite LBQ657

although selective radioligands such as Ioflupane (¹²³I) are now available for this application

InChi: InChI=1S/C13H9Cl2N5/c14-11-5-1-4-10(12(11)15)13-17-18-19-20(13)8-9-3-2-6-16-7-9/h1-7H

AV-412 free base Size:Solid 10 mg a Rho-kinase inhibitorAV 412, also known as MP 412, is a second generation, orally bioavailable dual kinase inhibitor with potential antineoplastic activity. EGFR HER2 inhibitor AV 412 binds to and inhibits the epidermal growth factor receptor (EGFR) and the human epidermal growth factor receptor 2 (HER2), which may result in the inhibition of tumor growth and angiogenesis, and tumor regression in EGFR HER2 expressing tumors. This agent may be active against EGFR HER2

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