Tradipitant 5917 182(1):83-92

182(1):83-92

Smiles: NC(N)=NCCCCC(=O)NC1=CC(=CC(NC(=O)C2=CC(=NC=N2)C(=O)NC2=CC(=CC(NC(=O)CCCCN=C(N)N)=C2O[C@H]2CNCC2)C(F)(F)F)=C1O[C@H]1CNCC1)C(F)(F)F

Smiles: CN(CCNC)C(=O)OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H]3[C@H](O[C@@H]4[C@H](OCCN34)OC)[C@H](C)O2)C2=C(C1)C(O)=C1C(C(=O)C3C(=CC=CC=3C1=O)OC)=C2O

InChiKey: AANLWYRSPUHEKW-MIZQACOZSA-N

It is showed that tanshinones significantly inhibited A549 proliferation and Isocryptotanshinone (ICTS) exhibits the strongest activity

Tradipitant 5917 182(1):83-92Tradipitant (VLY 686) is a neurokinin 1 (NK 1) antagonist. Product information CAS Number: 622370 35 8 Molecular Weight: 587. 90 Formula: C28H16ClF6N5O Chemical Name: 2 (1 {[3,5 bis(trifluoromethyl)phenyl]methyl} 5 (pyridin 4 yl) 1H 1,2,3 triazol 4 yl) 3 (2 chlorobenzoyl)pyridine Smiles: O=C(C1=CC=CN=C1C1N=NN(CC2C=C(C=C(C=2)C(F)(F)F)C(F)(F)F)C=1C1C=CN=CC=1)C1=CC=CC=C1Cl InChiKey: CAVRKWRKTNINFF UHFFFAOYSA N InChi: InChI=1S C28H16ClF6N5O c29 22 6 2 1 4