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De Jager R
beneficial effects in animal models of various types of nephrosis and heart failure
SGI-1027 was used at 10-300 µM final concentration in various in vitro assays
Also degrades exon-14-deleted c-MET in Hs746T cells
InChiKey: LQGUBLBATBMXHT-UHFFFAOYSA-N
Genz-123346 - CAS# 943344-58-9 Size:Solid 2 mg De Jager RGenz 123346 is a potent and selective glucosylceramide synthase inhibitor with potential anticancer activity. Exposure of cells to Genz 123346 and to other GCS inhibitors at non toxic concentrations can enhance the killing of tumor cells by cytotoxic anti cancer agents. Genz 123346 and a few other GCS inhibitors are substrates for multi drug resistance efflux pumps such as P gp (ABCB1, gP 170). In cell lines selected to over express P gp or which