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WYE-132 targeted P-AKT(S473) and AKT function without significantly reducing the steady-state level of the PI3K/PDK1 activity biomarker P-AKT(T308)
Etomoxir has also been identified as a direct agonist of PPARα
InChiKey: WWONFUQGBVOKOF-UHFFFAOYSA-N
2*+1/p-2/t3-
WEHI-345 (20 mg/kg
Prucalopride succinate NE-493 WYE-132 targeted P-AKT(S473) and AKTPrucalopride, also known as R 108512, is a selective, high affinity serotonin (5 HT4) receptor agonist with enterokinetic activities. Prucalopride alters colonic motility patterns via serotonin 5 HT4 receptor stimulation: it stimulates colonic mass movements, which provide the main propulsive force for defecation. Prucalopride was approved for use in Europe in 2009. Product information CAS Number: 179474 85 2 Molecular Weight: 485. 96 Formula:
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