R-(+)-ETOMOXIR - CAS# 124083-20-1 093 Decreased activity and expression of

Decreased activity and expression of the cardiac sarcoplasmic reticulum calcium ATPase (SERCA2a)

InChiKey: VFSUUTYAEQOIMW-YHBQERECSA-N

while improving baseline sensory gating in mice

and lung metastasis in MMTV/c-Neu mice

300586-90-7

R-(+)-ETOMOXIR - CAS# 124083-20-1 093 Decreased activity and expression ofR (+) ETOMOXIR, CAS No. 124083 20 1, is an irreversible inhibitor of carnitine palmitoyltransferase 1 (CPT 1) on the outer face of the inner mitochondrial membrane. This prevents the formation of acyl carnitines, a step that is necessary for the transport of fatty acyl chains from the cytosol into the intermembrane space of the mitochondria. This step is essential to the production of ATP from fatty acid oxidation. Etomoxir has also been identified as