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Mirrione M
InChiKey: HZCOFZVJMJRKIB-UHFFFAOYSA-N
Smiles: CN(C1C=CC(=CC=1)C(F)(F)F)C(=O)C1=C(O)C2C(=CC=CC=2N(C)C1=O)OC
InChi: InChI=1S/C12H16N4O/c1-12(2
2018 Mar 1
TMP269 - Class IIa HDAC Inhibitor. CAS# 1314890-29-3 size:10mg solid Mirrione MTMP269, CAS No. 1314890 29 3, is a highly potent, selective and cell permeable class IIa HDAC inhibitor with IC50 of 126 nM, 80 nM, 36 nM and 19 nM for HDAC4, HDAC5, HDAC7 and HDAC9 respectively. It has very weak or no activity targeting the other HDACs (2 40 M). TMP269 has an unprecedented metal binding group, trifluoromethyloxadiazole (TFMO), which circumvents the selectivity and pharmacologic liabilities of hydroxamates. Crystallography revealed a
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