Others have pointed out that it comes as a kick in the teeth to those players who traded Wildcards for specific cards that may no longer be viable (or less viable) in the format
Hypnotic Specter Hypnotic Specter used to be a nasty black creature, but both threats and removal have become more efficient in our modern era of Magic, pushing this specter to the side
Its really cool seeing the interplay of the Affinity cards from the original Mirrodin block with the new colored Esper artifacts from Shards of Alara, for instance
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For gameplay, Id say its a crazy mix of action, survival, and crafting
While those older cards focused strictly on hand-refreshing, Misty's Vitality acts as massive Water-type acceleration, letting you search your deck for up to 4 Basic Water Energy cards and attach them directly to one of your Pokmon