MIPS-521 Catalog No.:M33388-100 InChi: InChI=1S/C5H8O4/c1-2-3(4(6)7)5(8)9/h3H

InChi: InChI=1S/C5H8O4/c1-2-3(4(6)7)5(8)9/h3H

C2HF3O2/c1-62(2)46-81(110(181)143-60-101(174)162-42-24-32-92(162)121(192)160-102(68(13)14)122(193)158-90(51-67(11)12)124(195)164-44-26-34-94(164)126(197)165-45-27-35-95(165)125(196)163-43-25-33-93(163)120(191)147-72(18)107(178)152-83(48-64(5)6)112(183)146-71(17)106(177)151-82(47-63(3)4)111(182)144-69(15)104(132)175)153-113(184)84(49-65(7)8)154-115(186)86(52-74-36-38-76(168)39-37-74)149-99(172)57-140-105(176)70(16)145-119(190)91(61-166)159-117(188)89(55-97(131)170)156-114(185)85(50-66(9)10)157-123(194)103(73(19)167)161-118(189)87(53-75-56-139-79-30-21-20-28-77(75)79)155-116(187)88(54-96(130)169)150-100(173)59-142-109(180)80(31-23-41-138-128(135)136)148-98(171)58-141-108(179)78(129)29-22-40-137-127(133)134

CAS Number: 5945-86-8

2-Methylcitric acid behaves as a potent inhibitor of glutamate oxidation by inhibiting glutamate dehydrogenase activity and as a permeability transition inducer

34)35/h4-11

MIPS-521 Catalog No.:M33388-100 InChi: InChI=1S/C5H8O4/c1-2-3(4(6)7)5(8)9/h3HMIPS 521 is a positive allosteric modulator of the A1R, exhibits analgesic efficacy in rats in vivo through modulation of the increased levels of endogenous adenosine that occur in the spinal cord of rats with neuropathic pain. We also report the structure of the A1R co bound to adenosine, MIPS521 and a Gi2 heterotrimer, revealing an extrahelical lipid detergent facing allosteric binding pocket that involves transmembrane helixes 1, 6 and 7. Molecular