Erastin xicillin Sodium Identification and Structure-Activity Relationships of

Identification and Structure-Activity Relationships of Novel Compounds that Potentiate the Activities of Antibiotics in Escherichia coli

is the most potent and selective Lysine Specific Demethylase-1 (LSD1) inhibitor reported to date

5 µM final concentration in various assays

Smiles: CN1C=C(C=N1)C1N=CN(CCC2C=NN(C)C=2)C=1C1=CC=C(C=C1)C#N

Diotallevi F

Erastin xicillin Sodium Identification and Structure-Activity Relationships ofErastin is an antitumor agent selective for tumor cells bearing oncogenic RAS (i. e. HRAS, KRAS). Erastin produces non apoptotic tumor cell death by altering mitochondrial voltage dependent anion channel (VDAC) gating allowing cations to enter mitochondria and leading to release of oxidative species causing oxidative cell death. Erastin blocks and reverses mitochondrial depolarization after microtubule destabilizers in intact cells and antagonized