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24)13-6-3-11(9-21-13)15(17
a cathepsin K inhibitor
is a potent inhibitor of Wnt/β-catenin signaling and colorectal cancer growth
InChiKey: CZSLEMCYYGEGKP-UHFFFAOYSA-N
InChi: InChI=1S/C5H4FN3O2/c6-2-1-8-5(11)3(9-2)4(7)10/h1H
LEE011 succinate hydrate(1:1:x) Catalog No.:M9046-2 24)13-6-3-11(9-21-13)15(17LEE011 succinate hydrate is an orally available cyclin dependent kinase (CDK) inhibitor targeting cyclin D1 CDK4 and cyclin D3 CDK6 cell cycle pathway, with potential antineoplastic activity. CDK4 6 inhibitor LEE011 specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation. Inhibition of Rb phosphorylation prevents CDK mediated G1 S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing