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(2013) J Med Chem
HIF pathway is the most significant pathway for cellular response to hypoxia
Dacinostat
115(17):3520-30
InChi: InChI=1S/C19H17F6N7O/c1-17(2
MALT1-MI-2 (MI-2) - MALT1 inhibitor. CAS# 1047953-91-2 429 (2013) J Med ChemMALT1 MI 2 (MI 2), CAS No. 1047953 91 2, is a highly potent and selective small molecule directly binding to MALT1 and irreversibly suppressing its protease function. MI 2 concentrated within human ABC DLBCL cells and irreversibly inhibited cleavage of MALT1 substrates with EC50 < 1 M (HBL 1 ~200 nM; TMD8 ~500 nM). This was accompanied by NF B pathway suppression, c REL nuclear localization inhibition, and NF B target gene downregulation. MI 2 was
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