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InChi: InChI=1S/C15H12N2OS2/c1-9-2-4-10(5-3-9)19-13-7-17-8-14-11(13)6-12(20-14)15(16)18/h2-8H
COC(=O)[C@@H]1[C@@H](O)CC[C@@H]2CN3CCC4C5=CC=CC=C5NC=4[C@@H]3C[C@@H]21
InChiKey: QKDDJDBFONZGBW-UHFFFAOYSA-N
modestly reduces in mean channel open time
VX-710 has been shown to restore sensitivity in a range of multidrug-resistant cells
MG-277 164015 InChi: InChI=1S/C15H12N2OS2/c1-9-2-4-10(5-3-9)19-13-7-17-8-14-11(13)6-12(20-14)15(16)18/h2-8HMG 277, a molecular glue degrader, effectively induces degradation of a translation termination factor, GSPT1, with a DC50 of 1. 3 nM. MG 277 potently inhibits tumor cell growth in a p53 independent manner, with IC50s of 3. 5 nM for RS4; 11 cells and 3. 4 nM for p53 mutant RS4; 11 IRMI 2 cells, respectively. Anticancer activity. Product information CAS Number: 2411085 89 5 Molecular Weight: 774. 71 Formula: C41H42Cl2FN5O5 Chemical Name: (3'R,4'S,5'R)
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