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Methods in mammalian autophagy research
PubMed PMID: 26456301
The highly polar carboxylate group of KDM5-C49 restricts its cellular permeability
CAS Number: 874902-19-9
PNU-74654 binds to β-catenin with a KD of 450 nM
Promethazine Hydrochloride torolac Methods in mammalian autophagy researchAbexinostat, also known as PCI 24781 or CRA 024781, is novel, broad spectrum hydroxamic acid based inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity. Abexinostat inhibits several isoforms of HDAC, resulting in an accumulation of highly acetylated histones, followed by the induction of chromatin remodeling; the selective transcription of tumor suppressor genes; and the tumor suppressor protein mediated inhibition of tumor
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