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9H2/t8-/m0/s1
10-trien-1-yl]sulfanyl}benzamide
Smiles: O=C(C1=CC=CC(F)=C1C1N=CC=CN=1)N1[C@H]2CC[C@@H]1C[C@H]2NC1=CN=C(C=N1)C(F)(F)F
InChi: InChI=1S/C12H11N3O4/c16-12-11(14-17)8-5-9(15(18)19)6-3-1-2-4-7(6)10(8)13-12/h5
6-difluoro-4-(1H-pyrazol-4-yl)phenyl]-3-oxoprop-1-enyl]-4-(1-methylpyrazol-4-yl)benzoate
CHMFL-ABL-053 21061 9H2/t8-/m0/s1CHMFL ABL 053 (compound 18a) is a BCR ABL inhibitor with ABL1: IC50 of 70 nM. CHMFL ABL 053 is derived from a dihydropyrimidopyrimidine core scaffold based compound 27 (GNF 7). CHMFL ABL 053 inhibited the proliferation of CML cell lines K562 (GI50 = 14 nM), KU812 (GI50 = 25 nM) and MEG 01 (GI50 = 16 nM), through significant suppression of the BCR ABL auto phosphorylation (EC50 = 100 nM) and downstream mediators such as STAT5, Crkl and ERK's
US$ 124.00
US$ 118.00