AZD-3463 - CAS# 1356962-20-3 yl Netupitant and IKZF3 proteins

and IKZF3 proteins

88(12):1971-8

and 4) both VDefactinib 25 mg/kg orally twice daily and PTX intraperitoneally weekly

5-fluoruracil

2146/ajhp120602

AZD-3463 - CAS# 1356962-20-3 yl Netupitant and IKZF3 proteinsAZD 3463 is a potent ALK IGF1R inhibitor with potential anticancer activity. AZD3463 inhibits neuroblastoma growth by overcoming crizotinib resistance and inducing apoptosis. AZD3463 effectively suppressed the proliferation of NB cell lines with wild type ALK (WT) as well as ALK activating mutations (F1174L and D1091N) by blocking the ALK mediated PI3K AKT mTOR pathway and ultimately induced apoptosis and autophagy. In addition, AZD3463 enhanced the