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respectively) as well as CYP3A4 metabolism of 7-benzyloxy-4-trifluoromethylcoumarin (BFC) and dibenzylfluorescein (DBF
74 with vehicle) at high glucose concentration (12
Formula: C23H32ClNO7
is a potent and selective allosteric protein arginine methyltransferase 3 (PRMT3) inhibitor with IC50 ~ 230 nM
chemokine receptor CXCR4
Emavusertib - CAS# 1801344-14-8 ericin B respectively) as well as CYP3A4Emavusertib, also known as CA 4948 is a potent IRAK4 FLT3 inhibitor with anti tumor activity. CA 4948 demonstrated good cellular activity in ABC DLBCL and AML cell lines. CA 4948 demonstrated moderate to high selectivity in a panel of 329 kinases as well as exhibited desirable ADME and PK profiles including good oral bioavailability in mice, rat, and dog and showed >90% tumor growth inhibition in relevant tumor models with excellent correlation with