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CCF-642 - CAS# 346640-08-2 size:2mg solid CAS Number: 440122-66-7

SKU: 70914792292

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Description

CAS Number: 440122-66-7

Chemical Name: Bleomycin sulfate

Recent advances in the development of specific antidotes for target-specific oral anticoagulants

CAS Number: 2622-24-4

Odanacatib dose-dependently reduces CTx release with an IC50=9

CCF-642 - CAS# 346640-08-2 size:2mg solid CAS Number: 440122-66-7CCF 642, CAS No. 346640 08 2, is a protein disulfide isomerase (PDI) inhibitor. CCF642 exhibited a submicromolar IC50 in 10 of 10 multiple myeloma cell lines. In vitro, CCF642 inhibited PDI reductase activity about 100 fold more potently than the structurally distinct established inhibitors PACMA 31 and LOC14. CCF642 displayed potent efficacy in an aggressive syngeneic mouse model of multiple myeloma and prolonged the lifespan of C57BL KaLwRij mice

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