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InChi: InChI=1S/C10H11NO4/c12-8-3-1-7(2-4-8)5-9(13)11-6-10(14)15/h1-4
5]undecan-5-one
ZK824859 (50
Novartis has since withdrawn its intent to submit vildagliptin to the FDA
Smiles: CN1CCN(CC1)C1=CC(NC2C=C(C)NN=2)=NC(=N1)SC1C=CC(=CC=1)NC(=O)C1CC1
SBI-797812 1095 InChi: InChI=1S/C10H11NO4/c12-8-3-1-7(2-4-8)5-9(13)11-6-10(14)15/h1-4SBI 797812 is structurally similar to active site directed NAMPT inhibitors and blocks binding of these inhibitors to NAMPT with EC50 of 0. 37 M. SBI 797812 shifts the NAMPT reaction equilibrium towards NMN formation, increases NAMPT affinity for ATP, stabilizes phosphorylated NAMPT at His247, promotes consumption of the pyrophosphate by product, and blunts feedback inhibition by NAD+. Treatment of cultured cells with SBI 797812 increases