TAS-103 dihydrochloride Size:Solid 2 mg COX-2 signaling pathway

COX-2 signaling pathway

+1/p-1/b14-9-

KRAS activity

Chemical Name: 2-(10-hydroxydecyl)-5

81 μM) by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1/Bcl-2 dual inhibitor Nap-1

TAS-103 dihydrochloride Size:Solid 2 mg COX-2 signaling pathwayTAS 103, also known as BMS 247615, is a quinoline derivative that displays antitumor activity in murine and human tumor models. TAS 103 has been reported to be a potent topoisomerase II poison. TAS 103 showed the strongest antitumor activity among the conventional anticancer agents for colorectal cancer (p<0. 05). The combination with CDDP augmented the antitumor activity of TAS 103 (p<0. 05), indicating that CDDP is one of the most potent candidates