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21)22)8-12(7-10)18(23
and appears to be well tolerated
KN-93 free base is a CaMKII inhibitor
Rigosertib induces apoptosis in chronic lymphocytic leukemia (CLL) cells without toxicity against T-cells or normal B-cells
Molecular Weight: 514
AC710 mesylate eridol D4 21)22)8-12(7-10)18(23AC710 is a potent, orally active, and selective platelet derived growth factor receptor family kinase inhibitor with potential anticancer activity. Its IC50 values are 1. 2, 2, 7. 7 and 10. 5 nM for KIT, FLT3, PDGFR and CSF1R respectively; Kd = 1. 3 nM for PDGFR.. AC710 causes tumor regression of leukemia cell xenografts in mice. AC710 also reduces joint swelling and inflammation in a mouse model of collagen induced arthritis. AC710 is now a
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