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a potent ROCK inhibitor
Smiles: CC1=C(/C=C2/C3=CC(F)=CC=C3NC/2=O)NC(C)=C1C(=O)NCCN1CCCC1
because its metabolites offer an alternative pathway to the urea cycle to allow excretion of excess nitrogen
Bardoxolone
SNS-032 induces a dose-dependent increase in annexin V staining and caspase-3 activation
Bendamustine Hydrochloride ntan Hydrochloride a potent ROCK inhibitorBendamustine is a bifunctional mechlorethamine derivative with alkylator and antimetabolite activities. Bendamustine possesses three active moieties: an alkylating group; a benzimidazole ring, which may act as a purine analogue; and a butyric acid side chain. Although its exact mechanism of action is unknown, this agent appears to act primarily as an alkylator. Bendamustine metabolites alkylate and crosslink macromolecules, resulting in DNA, RNA and