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113(41):E6219-E6227
Formula: C10H13N5O2
3-benzodioxol-5-yl)-1-[(dibutylcarbamoyl)methyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid hydrochloride
4-dichlorophenyl)-2-[(1H-1
The Hedgehog Pathway Effector Smoothened Exhibits Signaling Competency in the Absence of Ciliary Accumulation
TASIN-1 acytidine 113(41):E6219-E6227TASIN 1 is a small molecule inhibitor of mutant adenomatous polyposis coli (APC) . Adenomatous polyposis coli (APC) is a multifunctional tumor suppressor gene that is mutated in more than 80% of colon tumors. APC plays an important role in the negative regulation of canonical WNT signaling pathway through proteasomal degradation of b catenin. APC is involved in cell cycle control, migration, differentiation, and apoptosis . TASIN 1 is a selective
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