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is a BET bromodomain antagonist
IWR-1 inhibites the promoting effect of MIF on NSPC differentiation to neuron lineage
and inhibits NMDA-induced increase in cytosolic Ca2+ with IC50=13
a chemical probe targeting the bromodomains of BAZ2A and BAZ2B
Lappalainen J
Pyridostatin TFA salt - CAS# 1085412-37-8 167 is a BET bromodomain antagonistPyridostatin, CAS No. 1085412 37 8, stabilizes G quadruplexes (G4s) in cells and elicits a DNA damage response by causing the formation of DNA double strand breaks (DSB). Pyridostatin promotes growth arrest in human cancer cells by inducing replication and transcription dependent DNA damage. Pyridostatin targets gene bodies containing clusters of sequences with a propensity for G quadruplex formation. As a result, pyridostatin modulated the expression
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