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((4-((4-hydroxy-3-(1-methylethyl)phenyl)methyl)-3
Smiles: CC1N=CSC=1C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCCCCC(O)=O)C(C)(C)C)C=C1
Male Sprague-Dawley rats are dosed with the same IV (1 mg/kg) and PO (5
L 735524 sulfate
20 µg/mL and 30 µg/mL
PF-3644022 Catalog No.:M12254-2 ((4-((4-hydroxy-3-(1-methylethyl)phenyl)methyl)-3PF 3644022 is a potent, selective, orally active and ATP competitive MAPKAPK2 (MK2) inhibitor with an IC50 of 5. 2 nM and a Ki of 3 nM. PF 3644022 also inhibits MK3 and p38 regulated activated kinase (PRAK) with IC50s of 53 nM and 5. 0 nM, respectively. PF 3644022 potently inhibits TNF production and has anti inflammatory effect. Product information CAS Number: 1276121 88 0 Molecular Weight: 374. 46 Formula: C21H18N4OS Chemical Name: (15R) 15 methyl 5