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A permanent with hexproof may be exiled this way if its mana value is the greatest, for example

So youd want to use it on a powerful non-legendary creature or some kind of enchantment (like Warriors Resolve or Campsite Cuisine, for instance)

Most of the time youre going to be tutoring for Yawgmoths Will or Black Lotus when you have the win or tutoring for Necropotence when you dont

Now, youre probably wondering where Rapunzel, Gifted with Healing fits in all this

Some interaction is ultimately essential for the success of these decks, but the primary goal is always to get your opponent dead which Adanto Vanguard is very effective and resilient at achieving

She makes it super easy to crush any of the slower decks