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These decks have terrible mana that involves lands coming into play tapped

Be wary of Counterspell and Spell Snare before casting key spells, and avoid overextending into Supreme Verdict

Playing one side of the card doesn't mean the other remains permanently out of reachit just means you have to pay the mana cost of the other side to 'unlock' that room later

Yorion, Sky Nomad is still legal in the Pioneer format and Keruga, the Microsage and Obosh, the Preypiercer see some Modern and Pioneer play

an opposing artifact deck could win the game by attacking for lethal, or your artifacts could be destroyed by a common board wipe aimed at creatures like Damnation

If you can hardcast it and your deck is capable of holding off Burn and Abzan decks on its own, you'll find this very powerful whether it's in the opener or not