A card coming into play should be impactful at any stage of the game
The most recent printing, not counting the 30th Anniversary Edition that we all try to forget exists, is from 2007s Tenth Edition: In addition to the awesome new art (using the term new loosely here), Im sure you also notice the totally reworked text box
Whenever you cast a spell from anywhere other than your hand, Unstable Amulet deals 1 damage to each opponent
Anti-Venom, Horrifying Healer Anti-Venom, Horrifying Healer wants it all, a Pariah and any similar effect
The Forces of the Imperium deck brings all the Imperium factions into one set of cards, with the Space Marines, Imperial Guard, Adeptus Mechanicus and Sisters of Battle each making an appearance
If you have some of those, this looks quite good, but you need to have that support in place because a vanilla 3/4 for 4 is nowhere near good enough