Needless to say, I got the idea of simplifying from Sovereigns Realm
For example, Thoughtseize can deal with both Endurance and Spell Pierce, while also being an out to Rest in Peace or Sanctifier en -Vec if the opponent has them and we are short on more dedicated answers
That does not mean you should run zero interaction, but you should prioritize flexible cards that are not embarrassing when hit off Cascade
Windborn Muse For just 1 additional mana, this Windborn Muse is a Ghostly Prison with wings
Whenever one or more nonland cards are milled, put a +1/+1 counter on each of up to X target creatures, where X is the number of nonland cards milled this way
They will NOT fit other versions of One Piece or any other TCG Booster Boxes