Age counters can force your opponent to sacrifice their precious indestructible baby if they cant keep up with the cumulative upkeep cost, so making something like Mystic Remora indestructible won't achieve much
Universes Beyond Fallout introduces a brand new - and very nuclear wasteland-appropriate - mechanic in the form of radiation and its associated radial counters
"I will Giant Growth my Phyrexian Hydra, and Soul's FI-YA!" #3 - Goblin Grenade Before Fling, there was Goblin Grenade
Other cards with similar effects are Eternal Scourge and Torrent Elemental
With an unheard of 2 toughness, and prowess, and haste, for a single red mana, at common
Often runs Soul Spike as a powerful pseudo-burn that also gains its controller life and can be cast for free by exiling two black cards from hand - particularly powerful with Necropotence backing it up