Fateful hour If you have 5 or less life, those creatures gain indestructible until end of turn
For example you may want to build around Elminster because you love that character and the obvious choice would be to build around his abilities which involve scry mechanic, big spells, tokens and flying theme or even combinations of the above
Restoration Angel in particular makes it annoying to attack
You can also sort your cards by holograms
Cantrips like Opt and Consider are essential: they give me cheap card selection and the ability to dig for answers, and when paired with value engines like Talrand, Sky Summoner and Murmuring Mystic, they can add up to a massive board before long
In Commander, resolving one of these bad boys (or having one put into play via more nefarious means, such as with Muxus) is often enough for you to pull well ahead of your opponents on board