Obviously she still wants to be in a deck running as few noncreature spells as possible, but we can also add ways to remove Nikya from the battlefield to cast our noncreature spells, either bouncing her (Temur Sabretooth) or sacrificing her (High Market)
The Bad Wolf arc also makes an appearance on saga card The Parting of the Ways, which allows the player to add time counters before time travelling twice - using the sets time travel mechanic to add or remove time counters from suspended and permanent cards (with a token)
Bringing with her a number of Insect tokens equal to the number of creature cards in your graveyard, Izoni can easily deliver you an instant army in a dedicated self-mill strategy
This is a real issue when most Vintage Cubes have a Black Lotus, all the Moxen, Time Walk, and more
Mono blue frequently empowers combo decks, such as Urza, Lord High Artificer whose commander deck power level can creep into CEDH
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