Im actually in the camp that many of the 2 cmc Black removal spells are underrated in Modern, but the drawbacks on Go For the Throat and Doom Blade are relevant enough to keep them off this list
A 5-mana instant with literally no text is a major downside
The other parts you need are simply a zero-cost sacrifice outlet and some effect that can place a +1/+1 counter on creatures as they enter the battlefield: Grumgully, Path of Discovery, Juniper Order Ranger, or Rhythm of the Wild for example
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Coupled with cards such as Soul Warden, Souls Attendant, and Aetherflux Reservoir you can keep manipulating your life total as much as you please
