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Generally speaking, if your opponents have three or four poison counters on them when it resolves, you can be sure to take out a majority of their board, if not all of their creatures
Alexios, Deimos of Kosmos Mom, I want Slicer, Hired Muscle as my commander! We have Slicer at home. Alexios, Deimos of Kosmos is Slicer at home
Enchantments that do the same thing (draining life, paying life to draw cards or obtain resources) tend to add up
Can You Bargain a Spell Multiple Times
In fact, youll want all your different colors of mana to converge into a single spell