SC-10914 pferol 3-O-gentiobioside CAS Number: 149878-40-0

CAS Number: 149878-40-0

Chemical Name: (18S)-18-[(dimethylamino)methyl]-17-oxa-4

CAS Number: 207306-50-1

CAS Number: 2029049-79-2

Smiles: OC(=O)CCOCCOCCOCCOCCNC1C=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=1

SC-10914 pferol 3-O-gentiobioside CAS Number: 149878-40-0SC10914 is a highly potent PARP inhibitor (PARP1 IC50 = 7. 87 nM) with potent anti proliferative activity against human BRCA deficient tumor cells (MDA MB 436, BRCA1 deficient, IC50 = 4. 03 nM, Capan 1 BRCA2 deficient, IC50 = 11. 66 nM) and PTEN deficient tumor cells (HGC 27, PTEN deficient, IC50 = 0. 35 M). SC10914 showed potent anti tumor activity in BRCA1 2 mutant tumor models and better pharmacokinetics profile has the potential to be selected as