Cards like Breach the Multiverse, Expropriate, and Fevered Suspicion are ideal to cast for free, ramp to, or copy

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So, with that in mind
At 5 Generic and 2 Black to cast, you will really need some fast mana and protection to be able to both cast Toxrill and not get it blown up
Protection from Spells Emrakul, the Aeons Torn has a lot of text but hidden in it are the words protection from colored spells. A spell is anything currently on the stack
Overlord of Boilerbilges & Overlord of the Hauntwoods These two very powerful enchantment creatures can cheat their mana cost, and if there is anything that is always good in competitive magic it's the cheating of manacosts