This card is a huge difference maker in 2 weapon decks if used right, it is probably Guardian's most meta-defining card to the point it makes it really hard for the designers to make any sort of 'mid-grade' or 'backup' weapon in Guardian and heavily warps the card pool, but if you use it wrong it is going to make you miserable compared to running 4 weapons
There is no problem with using it in the game, but it is not recommended for those who purchased it for collection
Recurring threats that need to be exiled are usually very powerful and difficult to deal with for almost all decks, and Vengevine is a key piece in dredge decks since it benefits from self-mill and is one of the better payoffs for the strategy
Make You Work For It Many win conditions require a bit more work to pull off, but most of them come with additional value to either help you throughout the game or help assemble the win
But with the right Fusion card, its an instant Cyber End Dragon
in Commander, the uptick deals a collective 9 damage, which is easily exploited by commanders like Solphim, Mayhem Dominus