Cards like Toxic Deluge or Tragic Slip can effectively reduce an indestructible creature to 0 or negative toughness, and it will die
Dreadbore will kill a Titan and often you will main phase kill a Titan just to prevent them having some trickery post their untap and draw
While Prime Day deals are typically exclusive to Prime subscribers, this one happens to be available to everyone, so don't worry if you don't want to get Prime (or use the free trial)
Due to its high mana-curve and reduced focus on traditional creatures, its not unlikely that youll find yourself saddled with a bunch of quasi-creatures incapable of blocking
That said, dont let this hinder you in creating your own branch
After almost 30 years, out of the 31 cards that have been made, the Charizard Card is the only one that received a Gem Mint grade