With Grand Calcutron on the battlefield, your hands are the program so things that affect your hand affect the program
Picking out the best cards before a set is released is tricky, as it's hard to know how each card synergizes with the rest of the set and within each format
Cards like Isabella Madrigal, Caring Cultivator and Ming Lee, Giant Red Panda both interact with damage counters and healing, but The Madrigal Family only really offers high willpower and ink ramp, which isn't enough to offset the volume of other, more useful cards in this set
The heavy graveyard decks don't care that much, it can really hurt the more modest graveyard decks like welder though
After all, Shiny rare Pokemon are not actually all that difficult to pull
A card is considered functionally identical to another card if it has the same card type, subtypes, abilities, mana cost, power, and toughness