I might be a little biased on this one because I love Dimir colors, but I can see Ashiok having a significant impact in Standard
Alchemy: All Will Be One While we don't know a whole lot about it yet, it's been confirmed that we're getting an Alchemy set to accompany Phyrexia: All Will Be One
Attach it to your bomb creature and hope you can get some solid, unblockable swings in
Dragoon's Lance serves as an example, allowing each creature to be a potential threat, when combined with equipment to close out the game
An A-Line The card gives creatures an advantage, first strike, for having the lowest collector number
If another effect modifies how much damage your source would deal, including preventing some of it, the player being dealt damage or the controller of the permanent being dealt damage chooses an order in which to apply those effects