The only real matchup in which Wrenn and Six truly shines is against Control decks which dont have enough board presence to pressure it
This may seem like it's not that productive, as your opponent will often die to regular damage first, but a lot of what makes poison counters special in Phyrexia: All Will Be One is the Corrupted mechanic, which is an ability word that turns on when your opponent has three or more poison counters
The less human version is Tovolar, Midnight Scourge, whos a 4/4 with the same card draw ability, but this time around you can pay X, one red, and one green, to give a Wolf or Werewolf you control +x/+0 and trample until the end of the turn, which is a great way to finish someone off
If this Pokemon has at least 1 extra Energy attached to it in addition to this attack's cost, your opponent's Active Pokemon is now Burned and Confused
Land Color tag templates(None) Forest Basic Land - Forest Color tag templates(None) Haunted Mire ( : Add or .) This land enters tapped
Instinctively, you hold it high above the open book